Resolved: normal glomeruli filter nephrotic levels of albumin.
نویسندگان
چکیده
The glomerular filtration barrier has long been thought largely impermeable to albumin. Startling new data suggest it may not be especially important in this process. Much of the argument hinges on whether charge selectivity really exists, how feasible it is for enormous quantities of albumin to instead be reclaimed by the proximal tubule, and the technical merits of previous experiments. Three experts in the field debate the merits of this argument.
منابع مشابه
Nephrotic urine prevents increased rat glomerular albumin permeability induced by serum from the same patient with idiopathic nephrotic syndrome.
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متن کاملMicrosoft Word - NEF171BF
Prof. R. Lauwerys, Faculté de Médecine, Clos Chapelle-aux-Champs 30, B-1200 Bruxelles (Belgium) Dear Sir, The glomerular filtration barrier is both sizeand charge-selective. Fixed anionic sites within the glomerular basement membrane and on the epithelial cell coat appear to be the basis of the charge selectivity. This charge barrier restricts the passage across the filter of polyanionic macrom...
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ورودعنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 19 3 شماره
صفحات -
تاریخ انتشار 2008